[HTML][HTML] RUNX1 is a key target in t (4; 11) leukemias that contributes to gene activation through an AF4-MLL complex interaction
Summary The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator
required for the maintenance of gene activation during development. MLL chromosomal …
required for the maintenance of gene activation during development. MLL chromosomal …
The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis
H Osaki, V Walf-Vorderwülbecke, M Mangolini, L Zhao… - Leukemia, 2013 - nature.com
The most frequent chromosomal translocations in pediatric acute myeloid leukemia affect
the 11q23 locus and give rise to mixed lineage leukemia (MLL) fusion genes, MLL-AF9 …
the 11q23 locus and give rise to mixed lineage leukemia (MLL) fusion genes, MLL-AF9 …
Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6
M Liedtke, PM Ayton, TCP Somervaille… - Blood, The Journal …, 2010 - ashpublications.org
MLL is a common target for chromosomal translocations associated with acute leukemia
resulting in its fusion with a large variety of nuclear or cytoplasmic proteins that may activate …
resulting in its fusion with a large variety of nuclear or cytoplasmic proteins that may activate …
[HTML][HTML] CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
J Tan, M Jones, H Koseki, M Nakayama, AG Muntean… - Cancer cell, 2011 - cell.com
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene lead to the
development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is …
development of acute leukemias. Constitutive HOX gene activation by MLL fusion proteins is …
[HTML][HTML] MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia
OBJECTIVE: The aim of this study was to better understand how mixed lineage leukemia
(MLL) fusion proteins deregulate the expression of genes critical for leukemia. MATERIALS …
(MLL) fusion proteins deregulate the expression of genes critical for leukemia. MATERIALS …
[HTML][HTML] MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused
to> 60 different partner genes. In order to define a core set of MLL rearranged targets, we …
to> 60 different partner genes. In order to define a core set of MLL rearranged targets, we …
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
MG Guenther, LN Lawton, T Rozovskaia… - Genes & …, 2008 - genesdev.cshlp.org
Mixed-lineage leukemia (MLL) fusion proteins are potent inducers of leukemia, but how
these proteins generate aberrant gene expression programs is poorly understood. Here we …
these proteins generate aberrant gene expression programs is poorly understood. Here we …
Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia
AR Kumar, WA Hudson, W Chen, R Nishiuchi, Q Yao… - Blood, 2004 - ashpublications.org
Identification of the targets of mixed lineage leukemia (MLL) fusion genes will assist in
understanding the biology of MLL fusion gene leukemias and in development of better …
understanding the biology of MLL fusion gene leukemias and in development of better …
[HTML][HTML] MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele
Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-
type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) …
type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) …
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes
A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein
(MLL) N terminus to a variety of fusion partners that have been reported to reside in one or …
(MLL) N terminus to a variety of fusion partners that have been reported to reside in one or …