Aluminum-based adjuvants have widely been used in human vaccines since 1926. In the
absence of antigens, aluminum-based adjuvants can initiate the inflammatory preparedness …

Aluminum-based adjuvants are the most widely used adjuvants in human vaccines. A
comprehensive understanding of the mechanism of action of aluminum adjuvants at the …

Aluminum-containing adjuvants usually referred as Alum are considered as T helper type-2
(Th2) adjuvants, while agonists of toll-like receptors (TLRs) are viewed as adjuvants that …

Abstract Aluminum hydroxide (Al (OH) 3) and aluminum phosphate (AlPO 4) are widely used
adjuvants in human vaccines. However, a rationale to choose one or the other is lacking …

Adjuvants such as the aluminum compounds (alum) have been dominantly used in many
vaccines due to their immunopotentiation and safety records since 1920s. However, how …

Public interest in vaccines is at an all-time high following the SARS-CoV-2 global pandemic.
Currently, over 6 billion doses of various vaccines are administered globally each year. Most …

Abstract Background Aluminum-based adjuvants (ABAs) enhance the immune response
following vaccine injection. Their mechanisms of action are not fully understood, and their …

Adjuvant efficiency is critical for inducing a protective and long-lasting immune response
against weak immunogenic antigens. Discovered more than 70years ago, aluminum salts …

Aluminum-containing adjuvants have been used for over 90 years to enhance the immune
response to vaccines. Recent work has significantly advanced our understanding of the …

Adjuvants based on aluminum salts (Alum) are commonly used in vaccines to boost the
immune response against infectious agents. However, the detailed mechanism of how Alum …