Particle uptake in cancer cells can predict malignancy and drug resistance using machine learning

Y Goldstein, OT Cohen, O Wald, D Bavli, T Kaplan… - Science …, 2024 - science.org
Tumor heterogeneity is a primary factor that contributes to treatment failure. Predictive tools,
capable of classifying cancer cells based on their functions, may substantially enhance …

Triangular correlation (TrC) between cancer aggressiveness, cell uptake capability, and cell deformability

Y Brill-Karniely, D Dror, T Duanis-Assaf, Y Goldstein… - Science …, 2020 - science.org
The malignancy potential is correlated with the mechanical deformability of the cancer cells.
However, mechanical tests for clinical applications are limited. We present here a Triangular …

Altered physical phenotypes of leukemia cells that survive chemotherapy treatment

C Ly, H Ogana, HN Kim, S Hurwitz, EJ Deeds… - Integrative …, 2023 - academic.oup.com
The recurrence of cancer following chemotherapy treatment is a major cause of death
across solid and hematologic cancers. In B-cell acute lymphoblastic leukemia (B-ALL) …

Predicting cancer cell invasion by single-cell physical phenotyping

KD Nyberg, SL Bruce, AV Nguyen, CK Chan… - Integrative …, 2018 - academic.oup.com
The physical properties of cells are promising biomarkers for cancer diagnosis and
prognosis. Here we determine the physical phenotypes that best distinguish human cancer …

[HTML][HTML] Surface physical cues mediate the uptake of foreign particles by cancer cells

K Tischenko, Y Brill-Karniely, E Steinberg… - APL …, 2023 - pubs.aip.org
Cancer phenotypes are often associated with changes in the mechanical states of cells and
their microenvironments. Numerous studies have established correlations between cancer …

Machine-learning provides patient-specific prediction of metastatic risk based on innovative, mechanobiology assay

R Rozen, D Weihs - Annals of Biomedical Engineering, 2021 - Springer
Cancer mortality is mostly related to metastasis. Metastasis is currently prognosed via
histopathology, disease-statistics, or genetics; those are potentially inaccurate, not rapidly …

Nanomechanical analysis of cells from cancer patients

SE Cross, YS Jin, J Rao… - Nano-enabled medical …, 2020 - taylorfrancis.com
This chapter shows important implications for the combined use of imaging analysis with
nanomechanical measurements as a novel biomarker for evaluating and sensing changes …

[HTML][HTML] Machine learning analysis reveals tumor stiffness and hypoperfusion as biomarkers predictive of cancer treatment efficacy

D Englezos, C Voutouri, T Stylianopoulos - Translational Oncology, 2024 - Elsevier
In the pursuit of advancing cancer therapy, this study explores the predictive power of
machine learning in analyzing tumor characteristics, specifically focusing on the effects of …

Learning cancer-related drug efficacy exploiting consensus in coordinated motility within cell clusters

D Di Giuseppe, F Corsi, A Mencattini… - IEEE Transactions …, 2019 - ieeexplore.ieee.org
Objective: The ability of cells to collectively move is essential in various biological contexts
including cancer metastasis. In this paper, we propose an automatic video analysis tool to …

Rapid cancer diagnosis and early prognosis of metastatic risk based on mechanical invasiveness of sampled cells

Y Merkher, Y Horesh, Z Abramov, G Shleifer… - Annals of Biomedical …, 2020 - Springer
We provide an innovative, bioengineering, mechanobiology-based approach to rapidly (2-h)
establish the in vivo metastatic likelihood of patient tumor-samples, where results are in …