There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …

Background C-reactive protein (CRP) is associated with immune, cardiometabolic, and
psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal …

Importance Certain psychiatric and immune-related disorders are reciprocal risk factors.
However, the nature of these associations is unclear. Objective To characterize the …

Importance Observational studies highlight associations of C-reactive protein (CRP), a
general marker of inflammation, and interleukin 6 (IL-6), a cytokine-stimulating CRP …

Objective: Mental disorders are heritable and polygenic, and genome-wide genetic
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …

Background Genome-wide association studies have identified multiple risk variants for
psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders …

Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of
causal genetic variants that span much of the genome. This widespread polygenicity …

Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and
altered immune signaling. It is unclear whether these altered immunological states have a …

Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Although some existing epidemiological observations and molecular experiments
suggested that brain disorders in the realm of psychiatry may be influenced by immune …