Single-cell pathogen diagnostics for combating antibiotic resistance

H Li, K Hsieh, PK Wong, KE Mach, JC Liao… - Nature Reviews …, 2023 - nature.com
Bacterial infections and antimicrobial resistance are a major cause for morbidity and
mortality worldwide. Antimicrobial resistance often arises from antimicrobial misuse, where …

New technologies for rapid bacterial identification and antibiotic resistance profiling

SO Kelley - SLAS TECHNOLOGY: Translating Life Sciences …, 2017 - journals.sagepub.com
Conventional approaches to bacterial identification and drug susceptibility testing typically
rely on culture-based approaches that take 2 to 7 days to return results. The long turnaround …

Current and future technologies for the detection of antibiotic-resistant bacteria

D Yamin, V Uskoković, AM Wakil, MD Goni… - Diagnostics, 2023 - mdpi.com
Antibiotic resistance is a global public health concern, posing a significant threat to the
effectiveness of antibiotics in treating bacterial infections. The accurate and timely detection …

Emerging options for the diagnosis of bacterial infections and the characterization of antimicrobial resistance

S Rentschler, L Kaiser, HP Deigner - International Journal of Molecular …, 2021 - mdpi.com
Precise and rapid identification and characterization of pathogens and antimicrobial
resistance patterns are critical for the adequate treatment of infections, which represent an …

New molecular diagnostic approaches to bacterial infections and antibacterial resistance

EL Tsalik, RA Bonomo… - Annual review of medicine, 2018 - annualreviews.org
Recent advances in the field of infectious disease diagnostics have given rise to a number of
host-and pathogen-centered diagnostic approaches. Most diagnostic approaches in …

Recent and emerging technologies for the rapid diagnosis of infection and antimicrobial resistance

AJ Trotter, A Aydin, MJ Strinden, J O'grady - Current opinion in …, 2019 - Elsevier
Highlights•Rapid diagnostics are essential in the fight against antimicrobial
resistance.•BioFire® FilmArray® panels can identify pathogen resistance genes in 1 …

[PDF][PDF] Lineage calling can identify antibiotic resistant clones within minutes

K Břinda, A Callendrello, L Cowley, T Charalampous… - …, 2018 - scholar.harvard.edu
Antibiotic-resistant infections pose multiple challenges to healthcare systems, contributing to
higher mortality, morbidity, and escalating cost. Clinicians must regularly make rapid …

Targeted treatment for bacterial infections: prospects for pathogen-specific antibiotics coupled with rapid diagnostics

T Maxson, DA Mitchell - Tetrahedron, 2016 - Elsevier
The advent of antibiotics in the early twentieth century catalyzed a medical revolution,
drastically reducing mortality due to bacterial infections. Along with numerous other …

Unconventional screening approaches for antibiotic discovery

MA Farha, ED Brown - Annals of the New York Academy of …, 2015 - Wiley Online Library
The dramatic rise in microbial drug resistance in recent years has led to ongoing searches
for novel drugs to add to the armory against infectious disease. Nevertheless, a paucity of …

Mitigating the impact of antibacterial drug resistance through host-directed therapies: current progress, outlook, and challenges

CY Chiang, I Uzoma, RT Moore, M Gilbert… - MBio, 2018 - Am Soc Microbiol
Increasing incidences of multidrug resistance in pathogenic bacteria threaten our ability to
treat and manage bacterial infection. The development and FDA approval of novel …