Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA
modification processes have been reported, and they are widely present in every organism …

RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …

Over 170 chemical modifications have been identified in protein-coding and noncoding
RNAs and shown to exhibit broad impacts on gene expression. Dysregulation of RNA …

Post-transcriptional modifications in RNAs regulate their biological behaviors and functions.
N 1-methyladenosine (m 1 A), which is dynamically regulated by writers, erasers and …

RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …

Since the breakthrough discoveries of DNA and histone modifications, the field of RNA
modifications has gained increasing interest in the scientific community. The discovery of N6 …

Impaired gene regulation lies at the heart of many disorders, including developmental
diseases and cancer. Furthermore, the molecular pathways that control gene expression are …

ABSTRACT RNA plays essential roles in not only translating nucleic acids into proteins, but
also in gene regulation, environmental interactions and many human diseases. Nature uses …