P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells.
P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer …

P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The
protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of …

Clinical drug resistance to chemo therapeutic agents is a major obstacle for their curative
potential in the treatment of human cancers. Multidrug resistance (MDR) is an important …

P-glycoprotein-mediated multidrug resistance in tumor cells: Biochemistry, clinical relevance
and modulation - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …

Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A
mechanism underlying MDR is the overexpression of efflux transporters associated with …

The drug efflux transporter P-glycoprotein (P-gp) is known to confer multidrug resistance in
cancer chemotherapy. The P-gp is highly expressed in many types of tumor cells, as well as …

Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one
mechanism that tumor cells use to escape death induced by chemotherapeutic drugs …

Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …

Multidrug resistance represents a major obstacle in the successful therapy of neoplastic
diseases. Studies have demonstrated that this form of drug resistance occurs both in …

The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux
pump, as a mechanism of multidrug resistance in cancer is generally accepted as a …