Rationale: Understanding the role of the airway microbiome in chronic obstructive
pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome …

Background Alterations in the composition of the lung microbiome associated with adverse
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …

Background Recent studies suggest that lung microbiome dysbiosis, the disease associated
disruption of the lung microbial community, might play a key role in chronic obstructive …

Background Chronic obstructive pulmonary disease (COPD) is a progressive, life-
threatening lung disease with increasing prevalence and incidence worldwide. Increasing …

Specific bacterial species are implicated in the pathogenesis of exacerbations of chronic
obstructive pulmonary disease (COPD). However, recent studies of clinically stable COPD …

Increasing evidence suggests that the lung microbiome plays an important role in chronic
obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung …

Background The sputum microbiome has a potential role in disease phenotyping and risk
stratification in chronic obstructive pulmonary disease (COPD), but few large longitudinal …

Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a major source of
morbidity and contribute significantly to healthcare costs. Although bacterial infections are …

Background Chronic obstructive pulmonary disease (COPD) is a prevalent, progressive
respiratory disease, and acute exacerbations of COPD (AECOPD) can accelerate the …

In the past several years, advances in sequencing platforms and bioinformatics have
transformed our understanding of the relationship between microbial ecology and human …