Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

MAY Al-Nesf, HB Abdesselem, I Bensmail… - Nature …, 2022 - nature.com
COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …

Plasma proteomics identify biomarkers and pathogenesis of COVID-19

T Shu, W Ning, D Wu, J Xu, Q Han, M Huang, X Zou… - Immunity, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) pandemic is a global public health
crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Here …

Longitudinal plasma proteomics analysis reveals novel candidate biomarkers in acute COVID-19

Y Mohammed, DR Goodlett, MP Cheng… - Journal of proteome …, 2022 - ACS Publications
The host response to COVID-19 pathophysiology over the first few days of infection remains
largely unclear, especially the mechanisms in the blood compartment. We report on a …

Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission

J Calvet, A Berenguer-Llergo, M Gay, M Massanella… - Scientific reports, 2022 - nature.com
COVID-19 pathophysiology is currently not fully understood, reliable prognostic factors
remain elusive, and few specific therapeutic strategies have been proposed. In this scenario …

Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19

M Zoodsma, AH de Nooijer, I Grondman… - Frontiers in …, 2022 - frontiersin.org
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the highly
infectious Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). There is an …

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

J Park, H Kim, SY Kim, Y Kim, JS Lee, K Dan… - Scientific reports, 2020 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over forty
million patients worldwide. Although most coronavirus disease 2019 (COVID-19) patients …

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia

LM Palma Medina, H Babačić, M Dzidic, Å Parke… - Respiratory …, 2023 - Springer
Background COVID-19 remains a major public health challenge, requiring the development
of tools to improve diagnosis and inform therapeutic decisions. As dysregulated …

Longitudinal proteomic profiling provides insights into host response and proteome dynamics in COVID‐19 progression

JS Lee, D Han, SY Kim, KH Hong, M Jang, MJ Kim… - …, 2021 - Wiley Online Library
In managing patients with coronavirus disease 2019 (COVID‐19), early identification of
those at high risk and real‐time monitoring of disease progression to severe COVID‐19 is a …

Characterization by quantitative serum proteomics of immune-related prognostic biomarkers for COVID-19 symptomatology

M Villar, JM Urra, FJ Rodríguez-del-Río… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors
affecting disease progression and severity. The identification of prognostic biomarkers and …

Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms

W Zhong, O Altay, M Arif, F Edfors, L Doganay… - …, 2021 - thelancet.com
Background COVID-19 has caused millions of deaths globally, yet the cellular mechanisms
underlying the various effects of the disease remain poorly understood. Recently, a new …