Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …

Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at
the end of 2019, thousands of SARS-CoV-2 mutations have been increasingly observed …

A very recent work published in Advanced Science by our group reveals that 2′-deoxy-2′-
β-fluoro-4′-azidocytidine (Azvudine, FNC), a clinical candidate originally developed for HIV …

Abstract Coronavirus disease 2019 (COVID‐19) has spread worldwide. To date, no specific
drug for COVID‐19 has been developed. Thus, this randomized, open‐label, controlled …

In COVID‐19 patients, cytokine storm due to excessive immune responses can cause
severe complications. In this study, we investigated the effect of curcumin nanomicelles on …

Coronavirus disease 2019 (COVID-19) is a fatal respiratory illness caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The identification of potential drugs is …

Introduction The SARS-CoV-2 outbreak has threatened the human population globally as
the numbers of reinfection cases even after large-scale vaccination. Trials have been carried …

Conspectus Modified nucleosides show therapeutic promise for antiviral therapies.
However, issues including the emergence of drug resistance, toxicity, and coinfections have …

Background: On March 11, 2020, the World Health Organization (WHO) declared the
outbreak of coronavirus disease (COVID-19) a pandemic. Since then, thousands of people …

The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for
alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory …