The high prevalence of sickle haemoglobin in Africa shows that malaria has been a major
force for human evolutionary selection, but surprisingly few other polymorphisms have been …

Host genetic factors can confer resistance against malaria, raising the question of whether
this has led to evolutionary adaptation of parasite populations. Here we searched for …

Malaria causes approximately one million fatalities per year, mostly among African children.
Although highlighted by the strong protective effect of the sickle-cell trait,, the full impact of …

Genetic factors are known to have a role in determining susceptibility to infectious diseases,,
although it is unclear whether they may also influence host efficiency in transmitting …

Malaria has had a major effect on the human genome, with many protective polymorphisms—
such as the sickle-cell trait—having been selected to high frequencies in malaria-endemic …

ADHESION of parasitized erythrocytes to post-capillary venular endothelium1or uninfected
red cells'2–4 is strongly implicated in the pathogenesis of severe Plasmodlum faldparum …

New strategies are required to identify the most important targets of protective immunity in
complex eukaryotic pathogens. Natural selection maintains allelic variation in some …

The hemoglobinopathies, disorders of hemoglobin structure and production, protect against
death from malaria. In sub-Saharan Africa, two such conditions occur at particularly high …

As parasites, Plasmodium species depend upon their host for survival. During the blood
stage of their life-cycle parasites invade and reside within erythrocytes, commandeering host …

The ability to detect recent natural selection in the human population would have profound
implications for the study of human history and for medicine. Here, we introduce a framework …