Idiopathic pulmonary fibrosis (IPF) is an incurable complex genetic disorder that is
associated with sequence changes in 7 genes (MUC5B, TERT, TERC, RTEL1, PARN …

Idiopathic pulmonary fibrosis (IPF), a fatal disease that is a result of complex interactions
between genetics and the environment, has limited treatment options. We have identified the …

Genetic studies hold promise in helping to identify patients with early idiopathic pulmonary
fibrosis (IPF). Recent studies using chest computed tomograms (CTs) in smokers and in the …

Idiopathic pulmonary fibrosis is an etiologically complex interstitial lung disease
characterized by progressive scarring of the lungs with a subsequent decline in lung …

The airway epithelium serves as the interface between the host and external environment. In
many chronic lung diseases, the airway is the site of substantial remodeling after injury …

Results We identified 16 variants in the 4.2-kb 5′ promoter region of MUC5B within the six
GG and six TT study subjects with IPF. Each subject had a unique haplotype for the putative …

A Variant in the Promoter of <italic>MUC5B</italic> and Idiopathic Pulmonary Fibrosis Page 1
n engl j med 364;16 nejm.org april 21, 2011 1576 The new england journal of medicine …

There is clear evidence that environmental exposures and genetic predisposition contribute
to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Cigarette smoking increases the …

Both common and rare variants contribute to the genetic architecture of pulmonary fibrosis.
Genome-wide association studies have identified common variants, or those with a minor …

Background We previously identified a MUC5B gene promoter-variant that is a risk allele for
sporadic and familial Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia (IPF/UIP) …