Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Six years ago, DMM launched a subject collection called 'Drosophila as a Disease Model'.
This collection features Review-type articles and original research that highlight the power of …

With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

The ability of Drosophila genetics to reveal new insights into human neurodegenerative
disease is highlighted not only by mutants in flies that show neuronal cell loss, but also by …

Drosophila melanogaster is emerging as one of the most effective tools for analyzing the
function of human disease genes, including those responsible for developmental and …

The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Invertebrate model systems are powerful tools for studying human disease owing to their
genetic tractability and ease of screening. We conducted a mosaic genetic screen of lethal …

During the past year, the Drosophila genome has been sequenced. More than 60% of
genes implicated in human disease have Drosophila orthologues. Developments in RNA …

Drosophila melanogaster is a unique, powerful genetic model organism for studying a broad
range of biological questions. Human studies that probe the genetic causes of rare and …

A variety of studies that are currently underway may validate the fruit fly as an in vivo model
for analyzing genes involved in cardiac function. Many mutations in conserved genetic …