Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial
hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue …

Rheumatic diseases are characterized by sterile inflammation that causes severe long-term
damage to various organ systems. A growing body of evidence supports a pivotal role for the …

S100 proteins are low molecular weight calcium binding proteins expressed in vertebrates.
The family constitutes 21 known members that are expressed in several tissues and cell …

S100A12 is a member of the S100 protein family, which are intracellular calcium-binding
proteins. Although there are many reports on the involvement of S100A12 in inflammatory …

The metastasis-associated protein S100A4 belongs to the large family of S100 calcium-
binding proteins that appear to play regulatory roles in diverse biological activities …

Abstract S100A8 and S100A9, two Ca 2+-binding proteins of the S100 family, are secreted
as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages …

Aberrant adaptive immune responses and disturbed activation of innate immune
mechanisms are involved in the pathogenesis of arthritis and other autoinflammatory …

S100A4 (Mts1) belongs to the S100 family of calcium binding proteins, which are involved in
diverse biological regulatory activities. An association between S100A4 and tumor …

Objective: S100A8 and S100A9 are calcium binding proteins of the S100 family highly
expressed in neutrophils and monocytes. S100 proteins are novel ligands of TLR4 important …

Introduction The objective was to evaluate the changes in S100A8 S100A9, and their
complex (S100A8/S100A9) in cartilage during the onset of osteoarthritis (OA) as opposed to …