Oral mucosa and salivary gland are composed of complex and dynamic networks of
extracellular matrix, multiple cell types, vasculature, and various biochemical agents. Two …

Salivary glands (SGs) play a vital role in maintaining oral health through the production and
release of saliva. Injury to SGs can lead to gland hypofunction and a decrease in saliva …

Three-dimensional human oral mucosal models have been developed and optimized over
the past decades for different laboratory and clinical applications. This chapter focuses on …

Advances in tissue engineering have permitted the three-dimensional (3D) reconstruction of
human oral mucosa for various in vivo and in vitro applications. Tissue-engineered oral …

The salivary glands produce saliva and are important in maintaining oral health. Saliva
keeps the mouth moist, cleanses the oral cavity, aids digestion, and has antibacterial …

Tissue-engineered oral mucosa, in the form of epithelial cell sheets or full-thickness oral
mucosa equivalents, is a potential solution for many patients with congenital defects or with …

Replacement therapy for the salivary gland (SG) remains an unmet clinical need.
Xerostomia (“dry mouth”) due to hyposalivation can result from injury or disease to the SG …

Salivary gland (SG) functional damage and severe dry mouth (or xerostomia) are commonly
observed in a wide range of medical conditions from autoimmune to metabolic disorders as …

Research in mammalian cell biology often relies on developing in vitro models to enable the
growth of cells in the laboratory to investigate a specific biological mechanism or process …

Objective A challenge in studying human salivary glands is to maintain the cells ex vivo in
their three‐dimensional (3D) morphology with an intact native extracellular matrix (ECM) …