VASC: dimension reduction and visualization of single-cell RNA-seq data by deep variational autoencoder

D Wang, J Gu - Genomics, Proteomics and Bioinformatics, 2018 - academic.oup.com
Single-cell RNA sequencing (scRNA-seq) is a powerful technique to analyze the
transcriptomic heterogeneities at the single cell level. It is an important step for studying cell …

Dimensionality reduction and visualization of single-cell RNA-seq data with an improved deep variational autoencoder

J Jiang, J Xu, Y Liu, B Song, X Guo… - Briefings in …, 2023 - academic.oup.com
Single-cell RNA sequencing (scRNA-seq) is a revolutionary breakthrough that determines
the precise gene expressions on individual cells and deciphers cell heterogeneity and …

A deep adversarial variational autoencoder model for dimensionality reduction in single-cell RNA sequencing analysis

E Lin, S Mukherjee, S Kannan - BMC bioinformatics, 2020 - Springer
Background Single-cell RNA sequencing (scRNA-seq) is an emerging technology that can
assess the function of an individual cell and cell-to-cell variability at the single cell level in an …

A topology-preserving dimensionality reduction method for single-cell RNA-seq data using graph autoencoder

Z Luo, C Xu, Z Zhang, W Jin - Scientific reports, 2021 - nature.com
Dimensionality reduction is crucial for the visualization and interpretation of the high-
dimensional single-cell RNA sequencing (scRNA-seq) data. However, preserving …

Combining gene ontology with deep neural networks to enhance the clustering of single cell RNA-Seq data

J Peng, X Wang, X Shang - BMC bioinformatics, 2019 - Springer
Background Single cell RNA sequencing (scRNA-seq) is applied to assay the individual
transcriptomes of large numbers of cells. The gene expression at single-cell level provides …

Parameter tuning is a key part of dimensionality reduction via deep variational autoencoders for single cell RNA transcriptomics

Q Hu, CS Greene - … 2019: Proceedings of the Pacific Symposium, 2018 - World Scientific
Single-cell RNA sequencing (scRNA-seq) is a powerful tool to profile the transcriptomes of a
large number of individual cells at a high resolution. These data usually contain …

Visualization of single cell RNA-seq data using t-SNE in R

B Zhou, W Jin - Stem Cell Transcriptional Networks: Methods and …, 2020 - Springer
Single cell RNA sequencing (scRNA-seq) is a powerful tool to analyze cellular
heterogeneity, identify new cell types, and infer developmental trajectories, which has …

A comparison for dimensionality reduction methods of single-cell RNA-seq data

R Xiang, W Wang, L Yang, S Wang, C Xu… - Frontiers in genetics, 2021 - frontiersin.org
Single-cell RNA sequencing (scRNA-seq) is a high-throughput sequencing technology
performed at the level of an individual cell, which can have a potential to understand cellular …

Structure-preserving visualisation of high dimensional single-cell datasets

B Szubert, JE Cole, C Monaco, I Drozdov - Scientific reports, 2019 - nature.com
Single-cell technologies offer an unprecedented opportunity to effectively characterize
cellular heterogeneity in health and disease. Nevertheless, visualisation and interpretation …

Interpretable dimensionality reduction of single cell transcriptome data with deep generative models

J Ding, A Condon, SP Shah - Nature communications, 2018 - nature.com
Single-cell RNA-sequencing has great potential to discover cell types, identify cell states,
trace development lineages, and reconstruct the spatial organization of cells. However …