Vinyl sulfone with electrophilic character is not only a versatile building block for various
organic transformations but also is a key structural unit in a large number of biologically …

Cancer is the second leading cause of death worldwide. There is always a huge demand for
novel anticancer drugs and diverse new natural or synthetic compounds are developed …

The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …

Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif
which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin …

A novel series of purine derivatives containing sulfonamide moiety were synthesized in
good yield by the single-step reaction method. The purity of compounds was determined by …

The rise of drug-resistance has made the deserted clinical requirement to improve of new
classes of antibiotics agents. The development of antibacterial agents with the novel method …

The present review mainly focuses on discussing lead compounds and drugs that contain
cyclic sulfoxide and sulfone moieties together with appropriate consideration of the structure …

Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer
agents are major challenges for cancer treatment, which energizes medicinal chemists to …

Morpholine is a versatile moiety, a privileged pharmacophore and an outstanding
heterocyclic motif with wide ranges of pharmacological activities due to different …

The sulfonamide group is widely used in medicinal chemistry and appears in many
marketed drugs in a variety of forms. One class of drugs that contain this group has been …