Cellular senescence is regarded as an irreversible cell cycle arrest associated with tissue
aging and its functional decline. A senescence response is also evoked by oncogenic and …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates further
expansion of (pre-) malignant cells. Senescence imposes a tumor-suppressive barrier in …

A cell's genomic integrity is at risk when DNA-damaging stress, evoked by mitogenic
oncogenes or genotoxic treatment modalities such as radiation or chemotherapy, apply. If …

Cellular senescence is an irreversible arrest of proliferation. It is activated when a cell
encounters stress such as DNA damage, telomere shortening or oncogene activation. Like …

Activated RAS/BRAF oncogenes induce cellular senescence as a tumor-suppressive barrier
in early cancer development, at least in part, via an oncogene-evoked DNA damage …

Cellular senescence is a response to nonlethal intrinsic or extrinsic stress that results in
persistent growth arrest with a distinct morphological and biochemical phenotype. The …

Introduction Premature senescence is a permanent proliferative arrest that occurs in
response to oncogenic signaling or DNA-damaging chemotherapy. Although tumor cell …

Cellular senescence is a tumor suppressive response that has become recognized as a
major contributor of tissue aging. Senescent cells undergo a stable proliferative arrest that …

Simple Summary Senescence is a form of cell cycle arrest induced by stresses such as DNA
damage and oncogenes and therefore constitutes a crucial barrier against cancer …

Cellular senescence is a tumor‐suppressor mechanism that has been shown to occur in
response to multiple signals, including oncogenic stress, DNA damage, oxidative stress …