Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is activated in chronic inflammatory states,
eg, in the aging process and age-related diseases. IDO1 enzyme catabolizes L-tryptophan …

Chronic low-grade inflammation is a common hallmark of the aging process and many age-
related diseases. There is substantial evidence that persistent inflammation is associated …

Indoleamine 2, 3-dioxygenase (IDO), an enzyme degrading tryptophan (trp) to kynurenine
(kyn), suppresses T cell activity. Ageing of the immune system, immunosenescence …

The IDO/kynurenine pathway is now established as a major regulator of immune system
function. The initial enzyme, indoleamine 2, 3-dioxygenase (IDO1) is induced by IFNγ, while …

Abstract The enzyme indoleamine 2, 3‐dioxygenase 1 (IDO 1) catalyses the initial, rate‐
limiting step in tryptophan (Trp) degradation, resulting in tryptophan starvation and the …

The kynurenine (Kyn) pathway is the major route for tryptophan (Trp) metabolism, and it
contributes to several fundamental biological processes. Trp is constitutively oxidized by …

Abstract Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the
degradation pathway of the essential amino acid tryptophan and is expressed by …

IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …

Indoleamine 2, 3‐dioxygenase 1 (IDO1), the L‐tryptophan‐degrading enzyme, plays a key
role in the immunomodulatory effects on several types of immune cells. Originally known for …

Indoleamine 2, 3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative
degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine …