Obtaining sequential and conformational information on proteins is vital to understand their
functions. Although the nanopore-based electrical detection can sense single molecule (SM) …

Direct structural and dynamic characterization of protein conformers in solution is highly
desirable but currently impractical. Herein, we developed a single molecule gold plasmonic …

DNA and amino acids are important biomolecules in living organisms. Probing such
biomolecules with structural characters can provide valuable information for life study. Here …

Conventional ion current-based nanopore techniques that identify single molecules are
hampered by limitations of providing only the ionic current information. Here, we introduce a …

Single protein sensing based on solid-state nanopores is promising but challenging,
because the fast translocation velocity of a protein is beyond the bandwidth of nanopore …

Probing the orientation and oxygenation state of single molecules (SMs) is of great
importance for understanding the advanced structure of individual molecules. Here, we …

Sequence identification of peptides and proteins is central to proteomics. Protein
sequencing is mainly conducted by insensitive mass spectroscopy because proteins cannot …

Plasmonics is the discipline that investigates the use of collective oscillations of conductive
electrons in metallic nanostructures, called surface plasmons (SPs), to realize a large set of …

Nanopores are promising single-molecule tools for the electrical identification and
sequencing of biomolecules. However, the characterization of proteins, especially in real …

The impressive success of DNA sequencing using nanopores makes it possible to realize
nanopore based protein sequencing. Well-controlled capture and linear movement of the …