A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

Traditionally, idiopathic hypogonadotropic hypogonadism (IHH) is divided into two major
categories: Kallmann syndrome (KS) and normosmic IHH (nIHH). To date, inactivating …

Hypogonadotropic hypogonadism (HH) often manifests as pubertal delay. A considerable
proportion of cases of HH is due to genetic mutations. Recognizing those mutated genes …

Context Congenital hypogonadotropic hypogonadism (CHH) is a rare condition caused by
GnRH deficiency. Several genes have been associated with the pathogenesis of CHH, but …

Determining the physiologic influences that modulate GnRH secretion, the prime initiator of
reproductive function in the human, is fundamental not only to our understanding of the rare …

Hypothalamic gonadotropin releasing hormone (GnRH) is a key player in normal puberty
and sexual development and function. Genetic causes of isolated hypogonadotropic …

Hypogonadotropic hypogonadism is characterized by failure of gonadal function secondary
to deficient gonadotropin secretion, resulting from either a pituitary or hypothalamic defect …

Objective Congenital hypogonadotropic hypogonadism (CHH) and constitutional delay of
growth and puberty (CDGP) represent rare and common forms of GnRH deficiency …

Congenital hypogonadotropic hypogonadism (CHH) results from abnormal gonadotropin
secretion, and it is characterized by impaired pubertal development. CHH is caused by …

Congenital hypogonadotropic hypogonadism (CHH) is a clinically and genetically
heterogeneous congenital disease. Symptoms cover a wide spectrum from mild forms to …