Although largely deprived from exogenous stimuli in utero, the mucosal barriers of the
neonate after birth are bombarded by environmental, nutritional, and microbial exposures …

The mucosal surfaces of the gut and airways have important barrier functions and regulate
the induction of immunological tolerance. The rapidly increasing incidence of chronic …

Our environment poses a constant threat to our health. To survive, all organisms must be
able to discriminate between good (food ingredients and microbes that help digest our food) …

The mucosal immune system of neonates goes through successive, non-redundant phases
that support the developmental needs of the infant and ultimately establish immune …

Highlights•In utero microbial stimulation modulates both prenatal and postnatal immune cell
development.•Unique neonatal gut microenvironment allows for progressive colonization of …

Fetal and neonatal development represents a critical window for setting a path toward health
throughout life. In this review, we focus on intestinal immunity, how it develops, and its …

The immune system of infants is actively downregulated during pregnancy and therefore the
first months of life represent a period of heightened susceptibility to infection. After birth …

Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant
development during the first years of life. This microbial settlement occurs in parallel with the …

Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual
on a trajectory toward health or disease. Little is known about these early-life events in the …

The intestinal tract is engaged in a relationship with a dense and complex microbial
ecosystem, the microbiota. The establishment of this symbiosis is essential for host …