Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19

AK Ghosh, JL Mishevich, A Mesecar… - ChemMedChem, 2022 - Wiley Online Library
Abstract COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public
health crisis around the globe. Development of vaccines and the first cluster of antiviral …

[HTML][HTML] An update review of emerging small-molecule therapeutic options for COVID-19

D Tian, Y Liu, C Liang, L Xin, X Xie, D Zhang… - Biomedicine & …, 2021 - Elsevier
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a
challenge to global health. At present, many candidate small-molecule therapeutics have …

[HTML][HTML] Drug discovery strategies for SARS-CoV-2

ZA Shyr, K Gorshkov, CZ Chen, W Zheng - Journal of Pharmacology and …, 2020 - ASPET
Coronavirus disease 2019 (COVID-19) is a novel disease caused by the severe acute
respiratory syndrome coronavirus (SARS-CoV)-2 virus that was first detected in December of …

Viral target and metabolism‐based rationale for combined use of recently authorized small molecule COVID‐19 medicines: Molnupiravir, nirmatrelvir, and remdesivir

D Yan, B Yan - Fundamental & Clinical Pharmacology, 2023 - Wiley Online Library
The COVID‐19 pandemic remains a major health concern worldwide, and SARS‐CoV‐2 is
continuously evolving. There is an urgent need to identify new antiviral drugs and develop …

[HTML][HTML] Current strategies of antiviral drug discovery for COVID-19

M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

Recent advances in small-molecular therapeutics for COVID-19

L Zhong, Z Zhao, X Peng, J Zou… - Precision Clinical …, 2022 - academic.oup.com
The COVID-19 pandemic poses a fundamental challenge to global health. Since the
outbreak of SARS-CoV-2, great efforts have been made to identify antiviral strategies and …

Quest for a cure: potential small-molecule treatments for COVID-19, part 2

DL Hughes - Organic Process Research & Development, 2021 - ACS Publications
During the first year of the outbreak of the COVID-19 pandemic, many drugs and drug
candidates have been evaluated as treatment options. None yet has proved to be an …

Therapeutic targets and potential agents for the treatment of COVID‐19

Y Wu, Z Li, YS Zhao, YY Huang… - Medicinal research …, 2021 - Wiley Online Library
The outbreak of coronavirus disease 2019 (COVID‐19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, has become a global crisis. As …

[HTML][HTML] Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal Transduction and Targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

[HTML][HTML] Potential anti-SARS-CoV-2 therapeutics that target the post-entry stages of the viral life cycle: A comprehensive review

RA Al-Horani, S Kar - Viruses, 2020 - mdpi.com
The coronavirus disease-2019 (COVID-19) pandemic continues to challenge health care
systems around the world. Scientists and pharmaceutical companies have promptly …