Severe SARS-CoV-2 infection is associated with strong inflammation and autoantibody
production against diverse self-antigens, suggesting a system-wide defect in B cell …

Discovery of durable memory B cell (MBC) subsets against neutralizing viral epitopes is
critical for determining immune correlates of protection from SARS-CoV-2 infection. Here, we …

Objectives SARS‐CoV‐2 infection induces virus‐reactive memory B cells expressing
unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics …

Memory B cells are comprised of unswitched (CD27+ IgD+) and switched (CD27+ IgD-)
subsets. The origin and function of unswitched human memory B cells are debated in the …

A comprehensive understanding of the kinetics and evolution of the human B cell response
to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and …

Preexisting immunity against SARS-CoV-2 may have critical implications for our
understanding of COVID-19 susceptibility and severity. The presence and clinical relevance …

Individuals with the 2019 coronavirus disease (COVID-19) show varying severity of the
disease, ranging from asymptomatic to requiring intensive care. Although monoclonal …

Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …

Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2–
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …

B cells secrete antibodies and mediate the humoral immune response, making them
extremely important in protective immunity against SARS-CoV-2, which caused the …