Discovery and systematic assessment of early biomarkers that predict progression to severe COVID-19 disease

K Hufnagel, A Fathi, N Stroh, M Klein… - Communications …, 2023 - nature.com
Background The clinical course of COVID-19 patients ranges from asymptomatic infection,
via mild and moderate illness, to severe disease and even fatal outcome. Biomarkers which …

Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission

J Calvet, A Berenguer-Llergo, M Gay, M Massanella… - Scientific reports, 2022 - nature.com
COVID-19 pathophysiology is currently not fully understood, reliable prognostic factors
remain elusive, and few specific therapeutic strategies have been proposed. In this scenario …

A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning

MA Patel, M Daley, LR Van Nynatten, M Slessarev… - Clinical Proteomics, 2024 - Springer
Background COVID-19 is a complex, multi-system disease with varying severity and
symptoms. Identifying changes in critically ill COVID-19 patients' proteomes enables a better …

Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

MAY Al-Nesf, HB Abdesselem, I Bensmail… - Nature …, 2022 - nature.com
COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …

Longitudinal proteomic profiling provides insights into host response and proteome dynamics in COVID‐19 progression

JS Lee, D Han, SY Kim, KH Hong, M Jang, MJ Kim… - …, 2021 - Wiley Online Library
In managing patients with coronavirus disease 2019 (COVID‐19), early identification of
those at high risk and real‐time monitoring of disease progression to severe COVID‐19 is a …

A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: an observational multi-cohort study

Z Wang, A Cryar, O Lemke, P Tober-Lau… - …, 2022 - thelancet.com
Background Global healthcare systems continue to be challenged by the COVID-19
pandemic, and there is a need for clinical assays that can help optimise resource allocation …

Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics

B Di, H Jia, OJ Luo, F Lin, K Li, Y Zhang… - Signal transduction and …, 2020 - nature.com
Recent study showed that around 80% of coronavirus disease-19 (COVID-19) patients are
moderate cases who will recover with or without conventional treatment, while the remaining …

Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms

W Zhong, O Altay, M Arif, F Edfors, L Doganay… - …, 2021 - thelancet.com
Background COVID-19 has caused millions of deaths globally, yet the cellular mechanisms
underlying the various effects of the disease remain poorly understood. Recently, a new …

Molecular markers for early stratification of disease severity and progression in COVID-19

A Kashyap, SA Sebastian… - Biology Methods and …, 2022 - academic.oup.com
COVID-19 infections have imposed immense pressure on the healthcare system of most
countries. While the initial studies have identified better therapeutic and diagnostic …

Characterization by quantitative serum proteomics of immune-related prognostic biomarkers for COVID-19 symptomatology

M Villar, JM Urra, FJ Rodríguez-del-Río… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic caused by SARS-CoV-2 challenges the understanding of factors
affecting disease progression and severity. The identification of prognostic biomarkers and …