A large-scale candidate gene association study of blood pressure change in children and adolescents

EV Feofanova - 2015 - search.proquest.com
Hypertension, which affects about one-third of adults worldwide, is a major risk factor for the
morbidity and mortality associated with cardiovascular diseases (CVDs) and end-stage …

International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents

PG Parmar, HR Taal, NJ Timpson… - Circulation …, 2016 - Am Heart Assoc
Background—Our aim was to identify genetic variants associated with blood pressure (BP)
in childhood and adolescence. Methods and Results—Genome-wide association study data …

Genome-wide profiling of blood pressure in adults and children

HR Taal, GC Verwoert, A Demirkan… - …, 2012 - Am Heart Assoc
Hypertension is an important determinant of cardiovascular morbidity and mortality and has
a substantial heritability, which is likely of polygenic origin. The aim of this study was to …

[DOC][DOC] Hypertension: Over 1,000 genetic loci influencing blood pressure with multiple systems and tissues implicated

CP Cabrera, FL Ng, HL Nicholls, A Gupta, MR Barnes… - openaccess.sgul.ac.uk
High blood pressure remains the major heritable and modifiable risk factor for
cardiovascular disease (CVD). Persistent high blood pressure, or hypertension, is a complex …

Gene-based association study reveals a distinct female genetic signal in primary hypertension

R Zucker, M Kovalerchik, M Linial - Human Genetics, 2023 - Springer
Hypertension is a polygenic disease that affects over 1.2 billion adults aged 30–79
worldwide. It is a major risk factor for renal, cerebrovascular, and cardiovascular diseases …

Influence of obesity on association between genetic variants identified by genome-wide association studies and hypertension risk in Chinese children

B Xi, X Zhao, GR Chandak, Y Shen… - American journal of …, 2013 - academic.oup.com
BACKGROUND Childhood hypertension is a complex disease influenced by both genetic
and environmental factors. We aimed to examine how obesity status influences the …

Genome-wide association studies and beyond: what's next in blood pressure genetics?

X Wang, H Snieder - Hypertension, 2010 - Am Heart Assoc
In spite of recent successes for other complex diseases, essential hypertension has been
remarkably reluctant to reveal its underlying susceptibility genes through genomewide …

Generality of genomic findings on blood pressure traits and its usefulness in precision medicine in diverse populations: A systematic review

G Kolifarhood, MS Daneshpour, BS Khayat… - Clinical …, 2019 - Wiley Online Library
Remarkable findings from genome‐wide association studies (GWAS) on blood pressure
(BP) traits have made new insights for developing precision medicine toward more effective …

Genetic variants associated with systolic blood pressure in children and adolescents

MM Pike, J Schildcrout, S Baldwin… - Journal of the …, 2023 - Am Heart Assoc
Background Genetics, along with lifestyle and behavioral characteristics, play an important
role in hypertension in adults. Our aim was to identify genetic variants associated with blood …

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

V Tragante, MR Barnes, SK Ganesh… - The American Journal of …, 2014 - cell.com
Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate
genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure …