Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy

M Rudraraju, SP Narayanan, PR Somanath - Pharmacological research, 2020 - Elsevier
Loss of the blood-retinal barrier (BRB) integrity and subsequent damage to the
neurovascular unit in the retina are the underlying reasons for diabetic retinopathy (DR) …

[HTML][HTML] Protective factors in diabetic retinopathy: focus on blood-retinal barrier

C Zhang, H Wang, J Nie, F Wang - Discovery medicine, 2014 - discoverymedicine.com
The earliest and most significant change in diabetic retinopathy (DR) is blood-retinal barrier
(BRB) dysfunction, followed by two main pathologies that may cause severe visual …

[HTML][HTML] The inner blood-retinal barrier: Cellular basis and development

M Díaz-Coránguez, C Ramos, DA Antonetti - Vision research, 2017 - Elsevier
The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …

Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

I Klaassen, CJF Van Noorden… - Progress in retinal and …, 2013 - Elsevier
Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …

The blood–retina barrier in health and disease

F O'Leary, M Campbell - The FEBS journal, 2023 - Wiley Online Library
The blood–retina barrier (BRB) is the term used to define the properties of the retinal
capillaries and the retinal pigment epithelium (RPE), which separate the systemic circulation …

Molecular mechanisms of vascular permeability in diabetic retinopathy

DA Antonetti, E Lieth, AJ Barber… - Seminars in …, 1999 - Taylor & Francis
Diabetes leads to a wide array of complications in humans, including kidney failure, vascular
disease, peripheral nerve degeneration, and vision loss. Diabetic retinopathy causes …

Diabetic retinopathy: Breaking the barrier

RS Eshaq, AMZ Aldalati, JS Alexander, NR Harris - Pathophysiology, 2017 - Elsevier
Diabetic retinopathy (DR) remains a major complication of diabetes and a leading cause of
blindness among adults worldwide. DR is a progressive disease affecting both type I and …

Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes

D Navaratna, PG McGuire, G Menicucci, A Das - Diabetes, 2007 - Am Diabetes Assoc
OBJECTIVE—Increased vascular permeability due to alteration of the blood-retinal barrier
(BRB) is one of the major complications in early diabetes. The aim of the present study was …

The blood-retina barrier: tight junctions and barrier modulation

M Campbell, P Humphries - Biology and regulation of blood-tissue …, 2013 - Springer
The blood-retina barrier (BRB) is composed of both an inner and an outer barrier. The outer
BRB refers to the barrier formed at the retinal pigment epithelial (RPE) cell layer and …

Alterations to the blood–retinal barrier in diabetes: cytokines and reactive oxygen species

T Frey, DA Antonetti - Antioxidants & redox signaling, 2011 - liebertpub.com
Diabetic retinopathy (DR) is a leading cause of blindness in Western society. Since the
prevalence of diabetes continues to increase dramatically, the impact of DR will only worsen …