Liquid biopsies using cell-free RNA (cfRNA) can noninvasively measure dynamic
physiological changes throughout the body. While there is much effort in the liquid biopsy …

Background Liquid biopsy, particularly cell-free RNA (cfRNA), has emerged as a promising
non-invasive diagnostic tool for various diseases, including cancer, due to its accessibility …

Analyzing cell types of origin of cell-free RNA can enhance the resolution of liquid biopsies,
thereby deepening the understanding of molecular and cellular changes in development …

Single-cell RNA-sequencing has transformed the study of biological tissues by enabling
transcriptomic characterizations of their constituent cell states. Computational methods for …

Cell-free RNA (cfRNA) is a promising analyte for cancer detection. However, a
comprehensive assessment of cfRNA in individuals with and without cancer has not been …

Single-cell RNA sequencing data from complex human tissues are prone to blood
contamination in sample preparation, and some comprise cells of different genetic makeups …

Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin.
We extend this concept to identify cell types of origin using the Tabula Sapiens …

In biofluid, long RNAs are more informative than microRNAs in terms of gene number and
variation type. Therefore, cell-free long RNAs have shown promising potential as biomarkers …

Structured abstract Motivation The analysis of circulating cell-free DNA (cfDNA) holds
immense promise as a non-invasive diagnostic tool across various human conditions …

Cell type-specific gene expression (CSE) brings novel biological insights into both
physiological and pathological processes compared with bulk tissue gene expression …