Structure and assembly of the Ebola virus nucleocapsid

W Wan, L Kolesnikova, M Clarke, A Koehler, T Noda… - Nature, 2017 - nature.com
Ebola and Marburg viruses are filoviruses: filamentous, enveloped viruses that cause
haemorrhagic fever. Filoviruses are within the order Mononegavirales, which also includes …

Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution

Y Sugita, H Matsunami, Y Kawaoka, T Noda, M Wolf - Nature, 2018 - nature.com
Ebola virus causes haemorrhagic fever with a high fatality rate in humans and non-human
primates. It belongs to the family Filoviridae in the order Mononegavirales, which are viruses …

Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography

TAM Bharat, T Noda, JD Riches… - Proceedings of the …, 2012 - National Acad Sciences
Ebola virus is a highly pathogenic filovirus causing severe hemorrhagic fever with high
mortality rates. It assembles heterogenous, filamentous, enveloped virus particles containing …

The organisation of Ebola virus reveals a capacity for extensive, modular polyploidy

DR Beniac, PL Melito, SL Devarennes, SL Hiebert… - PloS one, 2012 - journals.plos.org
Background Filoviruses, including Ebola virus, are unusual in being filamentous animal
viruses. Structural data on the arrangement, stoichiometry and organisation of the …

Assembly of the Ebola virus nucleoprotein from a chaperoned VP35 complex

RN Kirchdoerfer, DM Abelson, S Li, MR Wood… - Cell reports, 2015 - cell.com
Ebolavirus NP oligomerizes into helical filaments found at the core of the virion,
encapsidates the viral RNA genome, and serves as a scaffold for additional viral proteins …

Functional mapping of the nucleoprotein of Ebola virus

S Watanabe, T Noda, Y Kawaoka - Journal of virology, 2006 - Am Soc Microbiol
At 739 amino acids, the nucleoprotein (NP) of Ebola virus is the largest nucleoprotein of the
nonsegmented negative-stranded RNA viruses, and like the NPs of other viruses, it plays a …

Electron cryo-microscopy structure of Ebola virus nucleoprotein reveals a mechanism for nucleocapsid-like assembly

Z Su, C Wu, L Shi, P Luthra, GD Pintilie, B Johnson… - Cell, 2018 - cell.com
Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral
nucleocapsid (NC) and serve as the scaffold for viral RNA synthesis. However, molecular …

The assembly of Ebola virus nucleocapsid requires virion-associated proteins 35 and 24 and posttranslational modification of nucleoprotein

Y Huang, L Xu, Y Sun, GJ Nabel - Molecular cell, 2002 - cell.com
Ebola virus encodes seven viral structural and regulatory proteins that support its high rates
of replication, but little is known about nucleocapsid assembly of this virus in infected cells …

Inclusion bodies are a site of ebolavirus replication

T Hoenen, RS Shabman, A Groseth, A Herwig… - Journal of …, 2012 - Am Soc Microbiol
Inclusion bodies are a characteristic feature of ebolavirus infections in cells. They contain
large numbers of preformed nucleocapsids, but their biological significance has been …

Mapping of the VP40-binding regions of the nucleoprotein of Ebola virus

T Noda, S Watanabe, H Sagara, Y Kawaoka - Journal of virology, 2007 - Am Soc Microbiol
Expression of Ebola virus nucleoprotein (NP) in mammalian cells leads to the formation of
helical structures, which serve as a scaffold for the nucleocapsid. We recently found that NP …