Importance Off-label use of prescription drugs has been identified as an important
contributor to preventable adverse drug events (ADEs) in children. Despite concerns …

Background Off-label prescribing may lead to adverse drug events. Little is known about its
prevalence and determinants resulting from challenges in documenting treatment indication …

Background Unlike medicines prescribed for Food and Drug Administration–approved
indications, off-label uses may lack rigorous scientific scrutiny. Despite concerns about …

Aims To investigate the potential relationship between off-label drug use and increased risk
of adverse drug reactions in paediatric outpatients. Methods A prospective …

OBJECTIVE: To study the characteristics of off-label prescribing and adverse drug reaction
(ADR) occurrence in a sample of pediatric outpatients treated by general practitioners …

FOLLOWING US FOOD and Drug Administra-tion (FDA) approval, clinicians may lawfully
prescribe a drug or biologic agent for treatment regimens not specified in the approved …

Objective: This systematic review summarizes the published incidence of off-label
medication use in children from the past 10 years. We also performed a retrospective chart …

Off-label prescribing is an integral part of contemporary medicine. Many patients benefit
when they receive drugs or devices under circumstances not specified on the label …

Background Off-label and unlicensed (OLUL) prescribing has been prevalent in pediatric
practice. Using data from a prospective cohort study of adverse drug reactions (ADRs) …

Study Objective. To develop a prioritized list of individual drugs for which future research
regarding off‐label uses is warranted. Design. Retrospective, cross‐sectional study. Data …