Increasing evidence has suggested that the HIV-1 capsid enters the nucleus in a largely
assembled, intact form. However, not much is known about how the cone-shaped capsid …

The movement of viruses and other large macromolecular cargo through nuclear pore
complexes (NPCs) is poorly understood. The human immunodeficiency virus type 1 (HIV-1) …

Human immunodeficiency virus type 1 (HIV-1) displays the unique ability to infect
nondividing cells. The capsid of HIV-1 is the viral determinant for viral nuclear import. To …

The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment
the core is released into the cytoplasm, it interacts with a range of cellular factors that …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

Delivering the virus genome into the host nucleus through the nuclear pore complex (NPC)
is pivotal in human immunodeficiency virus 1 (HIV-1) infection. The mechanism of this …

Nuclear import and uncoating of the viral capsid are critical steps in the HIV-1 life cycle that
serve to transport and release genomic material into the nucleus. Viral core import involves …

HIV-1 infection requires nuclear entry of the viral genome. Previous evidence suggests that
this entry proceeds through nuclear pore complexes (NPCs), with the 120× 60 nm capsid …

Background HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is
detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic …

Retroviral infection involves the reverse transcription of the viral RNA genome into DNA,
which is subsequently integrated into the host cell genome. Human immunodeficiency virus …