Iron overload, a high risk factor for many diseases, is seen in almost all human chronic and
common diseases. Iron chelating agents are often used for treatment but, at present, most of …

Balancing systemic iron levels within narrow limits is critical for human health, as both iron
deficiency and overload lead to serious disorders. There are no known physiologically …

The introduction of new iron chelating drugs may ultimately improve iron-chelation therapy
for patients with iron overload diseases such as thalassaemia and other disorders. In this …

Flavonoids are common plant natural products able to suppress ROS-related damage and
alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation …

Oxidative stress is a common denominator in the pathogenesis of many chronic diseases.
Therefore, antioxidants are often used to protect cells and tissues and reverse oxidative …

Excessive accumulation of iron in the body can lead to organ injury. Some flavonoids which
possess high affinity to iron can be used as iron chelators for curing iron overload diseases …

The health benefits of cranberries have long been recognized. However, the mechanisms
behind its function are poorly understood. We have investigated the iron-binding properties …

Iron is a life-supporting micronutrient that is required in the human diet, and is essential for
maintaining physiological homeostasis. Properly harnessing a redox-active metal such as …

Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …

Purpose There is general agreement that some dietary polyphenols block non-haem iron
uptake, but the mechanisms by which they achieve this action are poorly understood. Since …