Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …

We previously reported that induced activator protein‐1 (AP‐1) transcriptional activity
appears to be required for tumor promoter–induced transformation in mouse epidermal JB6 …

AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …

Tumor promoters may bring about events that lead to neoplastic transformation by inducing
specific promotion-relevant effector genes. Functional activation of the transacting …

AP-1 transcription factors play a critical role in signal transduction pathways in many cells.
We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and …

AP-1 transcriptional activity is stimulated by the transformation promoters phorbol 12-
myristate 13-acetate (" 12-O-tetradecanoylphorbol 13-acetate," TPA) and epidermal growth …

The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation,
transformation and death. Using mice and cells lacking AP-1 components, the target-genes …

We have previously demonstrated that the transition of melanoma to the metastatic
phenotype is associated with a loss of expression of the transcription factor AP-2. To further …

AP-1 is a sequence-specific transcriptional activator composed of members of the Jun and
Fos families (for review see Ref. 1). These proteins, which belong to the bZIP group of DNA …

We have stably expressed a trans-activation suppressing deletion mutant of the human c-jun
gene (TAM-67) in the malignant mouse epidermal cell lines 10Gy5 and PDV. Expression of …