Lipoprotein lipase: from gene to obesity

H Wang, RH Eckel - American Journal of Physiology …, 2009 - journals.physiology.org
Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …

Lipoprotein lipase: structure, function, regulation, and role in disease

JR Mead, SA Irvine, DP Ramji - Journal of molecular medicine, 2002 - Springer
Lipoprotein lipase (LPL) catalyses the hydrolysis of the triacylglycerol component of
circulating chylomicrons and very low density lipoproteins, thereby providing non-esterified …

Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high …

S Levak-Frank, W Hofmann… - Proceedings of the …, 1999 - National Acad Sciences
The tissue-specific expression of lipoprotein lipase (LPL) in adipose tissue (AT), skeletal
muscle (SM), and cardiac muscle (CM) is rate-limiting for the uptake of triglyceride (TG) …

Lipoprotein lipase: recent contributions from molecular biology

J Auwerx, P Leroy, K Schoonjans - Critical reviews in clinical …, 1992 - Taylor & Francis
Lipoprotein lipase (LPL) is a glycoprotein enzyme that is produced in several cells and
tissues. LPL belongs to a large lipase gene family that includes, among others, hepatic …

The role of lipoprotein lipase in adipose tissue development and metabolism

R Zechner, J Strauss, S Frank, E Wagner… - International Journal of …, 2000 - nature.com
Lipoprotein lipase (LPL) is essential for the hydrolysis and distribution of triglyceride-rich
lipoprotein-associated fatty acids among extrahepatic tissues. Additionally, the enzyme …

Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase

PH Weinstock, S Levak-Frank… - Proceedings of the …, 1997 - National Acad Sciences
Lipoprotein lipase (LPL) is the rate-limiting enzyme for the import of triglyceride-derived fatty
acids by muscle, for utilization, and adipose tissue (AT), for storage. Relative ratios of LPL …

Role of lipoprotein lipase in lipid metabolism

G Olivecrona - Current opinion in lipidology, 2016 - journals.lww.com
Role of lipoprotein lipase in lipid metabolism : Current Opinion in Lipidology Role of lipoprotein
lipase in lipid metabolism : Current Opinion in Lipidology Log in or Register Subscribe to …

Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism

K Preiss-Landl, R Zimmermann… - Current opinion in …, 2002 - journals.lww.com
Lipoprotein lipase: the regulation of tissue specific expres... : Current Opinion in Lipidology
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy …

Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance

LDMCB Ferreira, LK Pulawa, DR Jensen, RH Eckel - Diabetes, 2001 - Am Diabetes Assoc
Lipoprotein lipase (LPL) plays a rate-limiting role in triglyceride-rich lipoprotein metabolism
and is expressed in most tissues. Overexpression of LPL in skeletal muscle has been linked …

Physiological regulation of lipoprotein lipase

S Kersten - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2014 - Elsevier
The enzyme lipoprotein lipase (LPL), originally identified as the clearing factor lipase,
hydrolyzes triglycerides present in the triglyceride-rich lipoproteins VLDL and chylomicrons …