The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …

An evolutionarily conserved feature of cellular organelles is the distinct phospholipid
composition of their bounding membranes, which is essential to their identity and function …

Previous studies have established that the folding, structure and function of membrane
proteins are influenced by their lipid environments,,,,,, and that lipids can bind to specific …

The wealth of new data on membrane protein structures and functions is changing our
general view of membrane architecture. Some of the key themes that are emerging are that …

The structures and functions of organelles in cells depend on each other but have not been
systematically explored. We established stable knockout cell lines of peroxisomal, Golgi and …

Technological developments, especially in mass spectrometry and bioinformatics, have
revealed that living cells contain thousands rather than dozens of different lipids [for …

Eukaryotic cells have systems of internal organelles to synthesize lipids and membrane
proteins, to release secreted proteins, to take up nutrients and to degrade membrane-bound …

Cells determine the bilayer characteristics of different membranes by tightly controlling their
lipid composition. Local changes in the physical properties of bilayers, in turn, allow …

Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …

The distinct activities of organelles depend on the proper function of their membranes.
Coordinated membrane biogenesis of different organelles necessitates lipid transport from …