Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

New understanding in neuroscience has established that alongside the amyloid plaques,
neurofibrillary tangles and atrophy, the neuroinflammation triggered by the CNS's innate …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder of the
central nervous system. Since the first description of AD in 1907, many hypotheses have …

Biochemical and neuropathological studies of brains from individuals with Alzheimer
disease (AD) provide clear evidence for an activation of inflammatory pathways, and long …

The top-down, reductionist approach of the past three decades has resulted in remarkable
progress in identifying genes and proteins involved in Alzheimer's disease (AD), including β …

After years of failed therapeutic attempts targeting beta-amyloid (Aβ) in AD, there is now
increasing evidence suggesting that inflammation holds a pivotal role in AD pathogenesis …

Background Inflammation is a prominent feature in Alzheimer's disease (AD). It has been
proposed that aging has an effect on the function of inflammation in the brain, thereby …

Abstract The Alzheimer's Association's Research roundtable met in April 2015 to explore the
role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …