There is a large unmet medical need to develop disease-modifying treatment options for
individuals with age-related degenerative diseases of the central nervous system. The …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Assignee Company. Northwestern University [US/US]; 633 Clerk Street, Evanston, Illinois
60208, United States Disease Area. Alzheimer, s disease Biological Target. SIGMA-1 and …

Abstract The sigma-1 (σ 1) receptor has been associated with regulation of intracellular Ca
2+ homeostasis, several cellular signaling pathways, and inter-organelle communication, in …

Sigma-1 receptors are molecular chaperones that may act as pathological mediators and
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of senile dementia all over the world. Still no existing drugs can effectively reverse the …

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes
appear to share common mechanisms of neuronal cellular dysfunction, including …

Abstract The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …

Sigma receptors comprise a unique family of proteins that have been implicated in the
pathophysiology and treatment of many central nervous system disorders, consistent with …

Alzheimer's disease (AD) is an age-related neurodegenerative disease and characterized
by dementia, memory decline, loss of learning and cognitive disorder. The main pathological …