LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging

Z Yang, S Jiang, J Shang, Y Jiang, Y Dai, B Xu… - Ageing research …, 2019 - Elsevier
Fibrosis is universally observed in multiple aging-related diseases and progressions and is
characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various …

Role of lncRNAs in aging and age‐related diseases

J He, C Tu, Y Liu - Aging Medicine, 2018 - Wiley Online Library
Aging is progressive physiological degeneration and consequently declined function, which
is linked to senescence on both cellular and organ levels. Accumulating studies indicate that …

Long noncoding RNAs in aging and age-related diseases

S Kour, PC Rath - Ageing research reviews, 2016 - Elsevier
Aging is the universal, intrinsic, genetically-controlled, evolutionarily-conserved and time-
dependent intricate biological process characterised by the cumulative decline in the …

LncRNAs regulatory networks in cellular senescence

PK Puvvula - International journal of molecular sciences, 2019 - mdpi.com
Long noncoding RNAs (lncRNAs) are a class of transcripts longer than 200 nucleotides with
no open reading frame. They play a key role in the regulation of cellular processes such as …

The roles of lncRNA in hepatic fibrosis

H Peng, LY Wan, JJ Liang, YQ Zhang, WB Ai, JF Wu - Cell & bioscience, 2018 - Springer
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or
protein expression; however, their function in the progression of hepatic fibrosis remains …

Long non-coding RNA: Functional agent for disease traits

S Jain, N Thakkar, J Chhatai, M Pal Bhadra… - RNA biology, 2017 - Taylor & Francis
In recent years, long non-coding RNAs (lncRNAs) have attracted the attention of researchers
with their involvement in all facets of life. LncRNAs are transcripts of more than 200 …

Long noncoding RNAs in diseases of aging

J Kim, KM Kim, JH Noh, JH Yoon… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Aging is a process during which progressive deteriorating of cells, tissues, and organs over
time lead to loss of function, disease, and death. Towards the goal of extending human …

[HTML][HTML] Long non-coding RNAs in the failing heart and vasculature

S Hermans-Beijnsberger, M van Bilsen… - Non-coding RNA …, 2018 - Elsevier
Following completion of the human genome, it became evident that the majority of our DNA
is transcribed into non-coding RNAs (ncRNAs) instead of protein-coding messenger RNA …

Insights into biological role of LncRNAs in epithelial-mesenchymal transition

JT Cheng, L Wang, H Wang, FR Tang, WQ Cai, G Sethi… - Cells, 2019 - mdpi.com
Long non-coding RNAs (lncRNAs) are versatile regulators of gene expression and play
crucial roles in diverse biological processes. Epithelial-mesenchymal transition (EMT) is a …

Besides pathology: long non-coding RNA in cell and tissue homeostasis

A Salviano-Silva, SC Lobo-Alves, RC Almeida… - Non-coding RNA, 2018 - mdpi.com
A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …