An Evaluation of Type 1 Interferon Related Genes in Male and Female-Matched, SARS-CoV-2 Infected Individuals Early in the COVID-19 Pandemic
TP Huecksteadt, EJ Myers, SE Aamodt, S Trivedi… - Viruses, 2024 - mdpi.com
SARS-CoV-2 infection has claimed just over 1.1 million lives in the US since 2020. Globally,
the SARS-CoV-2 respiratory infection spread to 771 million people and caused mortality in …
the SARS-CoV-2 respiratory infection spread to 771 million people and caused mortality in …
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
[HTML][HTML] Immune phenotypes that predict COVID-19 severity
Severe COVID-19 causes profound immune perturbations, but pre-infection immune
signatures contributing to severe COVID-19 remain unknown. Genome-wide association …
signatures contributing to severe COVID-19 remain unknown. Genome-wide association …
Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome
KI Masood, M Yameen, J Ashraf, S Shahid… - Scientific reports, 2021 - nature.com
Understanding key host protective mechanisms against SARS-CoV-2 infection can help
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
outcomes ranging from asymptomatic to severe disease and death. We previously reported …
[HTML][HTML] Host transcriptional response to SARS‐CoV‐2 infection in COVID‐19 patients
Dear Editor, COVID-19 has an extremely variable prognosis, ranging from asymptomatic
and mildly affected individuals to severe disease and death. We have investigated the …
and mildly affected individuals to severe disease and death. We have investigated the …
Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia
HC Su, H Jing, Y Zhang… - Annual Review of …, 2023 - annualreviews.org
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …
Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients
Introduction There is insufficient understanding on systemic interferon (IFN) responses
during COVID-19 infection. Early reports indicated that interferon responses were …
during COVID-19 infection. Early reports indicated that interferon responses were …
[HTML][HTML] In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age
Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …
CoV-2) has shown a wide range of clinical manifestations in different patient populations …
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease
progression that suggest diverse host immune responses. We performed an integrated …
progression that suggest diverse host immune responses. We performed an integrated …