Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real‐world population‐based cohort

PCL Ferreira, Y Zhang, B Snitz… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma biomarkers—cost effective, non‐invasive indicators of Alzheimer's
disease (AD) and related disorders (ADRD)—have largely been studied in clinical research …

Confounding factors of Alzheimer's disease plasma biomarkers and their impact on clinical performance

A Pichet Binette, S Janelidze, N Cullen… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma biomarkers will likely revolutionize the diagnostic work‐up of
Alzheimer's disease (AD) globally. Before widespread use, we need to determine if …

Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study

AM Brickman, JJ Manly, LS Honig… - Alzheimer's & …, 2021 - Wiley Online Library
Abstract Introduction Blood‐based Alzheimer's disease (AD) biomarkers provide
opportunities for community studies and across ethnic groups. We investigated blood …

Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease

Z Xiao, X Wu, W Wu, J Yi, X Liang, S Ding… - Alzheimer's Research & …, 2021 - Springer
Background Plasma biomarkers showed a promising value in the disease diagnosis and
management of Alzheimer's disease (AD). However, profiles of the biomarkers and the …

Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia

XN Shen, JQ Li, HF Wang, HQ Li… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Plasma markers have been reported to be associated with brain amyloid
burden, tau pathology, or neurodegeneration. We aimed to evaluate whether plasma …

Plasma Aβ42/Aβ40 and p-tau181 predict long-term clinical progression in a cohort with amnestic mild cognitive impairment

Z Xiao, W Wu, X Ma, X Liang, J Lu, L Zheng… - Clinical …, 2022 - academic.oup.com
Background Previous studies reported the value of blood-based biomarkers in predicting
Alzheimer disease (AD) progression among individuals with different disease stages …

Proteomic Indicators of Health Predict Alzheimer's Disease Biomarker Levels and Dementia Risk

HE Dark, C Paterson, GN Daya, Z Peng… - Annals of …, 2024 - Wiley Online Library
Objective Few studies have comprehensively examined how health and disease risk
influence Alzheimer's disease (AD) biomarkers. The present study examined the association …

Plasma Aβ42/40 ratio, p‐tau181, GFAP, and NfL across the Alzheimer's disease continuum: a cross‐sectional and longitudinal study in the AIBL cohort

P Chatterjee, S Pedrini, JD Doecke… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma amyloid beta (Aβ) 1‐42/Aβ1‐40 ratio, phosphorylated‐tau181 (p‐
tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) are putative blood …

[HTML][HTML] Characterizing Plasma Biomarkers of Alzheimer's in a Diverse Community-Based Cohort: A Cross-Sectional Study of the HAB-HD Cohort

JR Hall, M Petersen, L Johnson, SE O'Bryant - Frontiers in Neurology, 2022 - frontiersin.org
Background Due to their low cost, less invasive nature, and ready availability, plasma
biomarkers of Alzheimer's disease have been proposed as one-time screening tools for …

Medical comorbidities and ethnicity impact plasma Alzheimer's disease biomarkers: important considerations for clinical trials and practice

SE O'Bryant, M Petersen, J Hall… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Despite the clinical implementation, there remain significant gaps in our
knowledge regarding the impact of race/ethnicity or common medical comorbidity on plasma …