Therapeutic mechanisms of lithium in bipolar disorder: recent advances and current understanding
Lithium is the most effective and well established treatment for bipolar disorder, and it has a
broad array of effects within cellular pathways. However, the specific processes through …
broad array of effects within cellular pathways. However, the specific processes through …
New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview
Over the last six decades, lithium has been considered the gold standard treatment for the
long-term management of bipolar disorder due to its efficacy in preventing both manic and …
long-term management of bipolar disorder due to its efficacy in preventing both manic and …
Potential mechanisms of action of lithium in bipolar disorder: Current understanding
Lithium has been used for over half a century for the treatment of bipolar disorder as the
archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in …
archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in …
[图书][B] Bipolar medications: mechanisms of action
HK Manji, CL Bowden, RH Belmaker - 2008 - books.google.com
Lithium, the treatment of choice for mania since its usefulness was first reported, has been
shown to have varied effects on multiple biological systems, including electrolyte flux and …
shown to have varied effects on multiple biological systems, including electrolyte flux and …
Glycogen synthase kinase-3: a target for novel bipolar disorder treatments
The enzyme glycogen synthase kinase-3 (GSK-3) is a direct target of lithium. While originally
recognized as an important molecule in a limited number of cellular processes, with unclear …
recognized as an important molecule in a limited number of cellular processes, with unclear …
Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks
RH Lenox, L Wang - Molecular psychiatry, 2003 - nature.com
The clinical efficacy of lithium in the prophylaxis of recurrent affective episodes in bipolar
disorder is characterized by a lag in onset and remains for weeks to months after …
disorder is characterized by a lag in onset and remains for weeks to months after …
Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications
TD Gould - Expert opinion on therapeutic targets, 2006 - Taylor & Francis
Historically, success in the pharmacological treatment of bipolar disorder has arisen either
from serendipitous findings or from studies with drugs (antipsychotics and anticonvulsants) …
from serendipitous findings or from studies with drugs (antipsychotics and anticonvulsants) …
[HTML][HTML] Inhibition of GSK3 by lithium, from single molecules to signaling networks
L Freland, JM Beaulieu - Frontiers in molecular neuroscience, 2012 - frontiersin.org
For more than 60 years, the mood stabilizer lithium has been used alone or in combination
for the treatment of bipolar disorder, schizophrenia, depression, and other mental illnesses …
for the treatment of bipolar disorder, schizophrenia, depression, and other mental illnesses …
Lithium as a neuroprotective agent for bipolar disorder: an overview
ELM Ochoa - Cellular and molecular neurobiology, 2022 - Springer
Lithium (Li+) is a first option treatment for adult acute episodes of Bipolar Disorder (BD) and
for the prophylaxis of new depressed or manic episodes. It is also the preferred choice as …
for the prophylaxis of new depressed or manic episodes. It is also the preferred choice as …
[HTML][HTML] Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
D Chatterjee, JM Beaulieu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …