Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications

XG Lei, JH Zhu, WH Cheng, Y Bao… - Physiological …, 2016 - journals.physiology.org
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

[HTML][HTML] Antioxidant responses and cellular adjustments to oxidative stress

C Espinosa-Diez, V Miguel, D Mennerich, T Kietzmann… - Redox biology, 2015 - Elsevier
Redox biological reactions are now accepted to bear the Janus faceted feature of promoting
both physiological signaling responses and pathophysiological cues. Endogenous …

An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase …

JB De Haan, PJ Crack, N Flentjar, RC Iannello… - Redox …, 2003 - Taylor & Francis
Aerobic cells are subjected to damaging reactive oxygen species (ROS) as a consequence
of oxidative metabolism and/or exposure to environmental toxins. Antioxidants limit this …

Antioxidants as therapies: can we improve on nature?

MP Murphy - Free Radical Biology and Medicine, 2014 - Elsevier
Although oxidative damage contributes to many pathologies the use of naturally occurring,
small-molecule antioxidants as therapies for these disorders has not been successful. Here I …

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024 - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

Endogenous antioxidants: a review of their role in oxidative stress

TAF Aguilar, BCH Navarro… - A master regulator of …, 2016 - books.google.com
Oxidative stress (OxS) constitutes a disturbance caused by an imbalance between the
generation of free radicals and antioxidant system, which causes damage to biomole‐-cules …

Mechanism of action of biological antioxidants

NI Krinsky - Proceedings of the Society for Experimental …, 1992 - journals.sagepub.com
More and more diseases have been proposed to have a radical or oxidant involvement.
Although in most cases we do not know if this involvement is a cause or a result of the …

[图书][B] Encyclopedia of molecular pharmacology

S Offermanns, W Rosenthal - 2021 - Springer
Antioxidants are molecules characterized by function rather than common structural motifs.
Their common feature is the capability of acting “anti”-oxidants in biological systems. Owing …

Antioxidant enzymes and human health

P Krishnamurthy, A Wadhwani - Antioxidant enzyme, 2012 - books.google.com
During normal metabolic functions, highly reactive compounds called free radicals are
generated in the body; however, they may also be introduced from the environment. These …

Understanding mechanisms of antioxidant action in health and disease

B Halliwell - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …