Objective The goal of this study was to investigate potential negative sequelae of orthodontic
force application±delivery of an osteoclast inhibitor, recombinant osteoprotegerin protein …

Background Because orthodontic tooth movement is dependent upon osteoclast-mediated
resorption of alveolar bone adjacent to the pressure side of tooth roots, biologic mediators …

The undesired movement of anchor teeth, and relapse of previously moved teeth, are major
clinical problems in orthodontics. Dental implants are increasingly used to preserve …

INTRODUCTION: The RANKL–OPG axis is a key regulator of osteoclastogenesis and bone
turnover activity. Its contribution to bone resorption under altered mechanical states …

Structured Abstract Objectives To assess the effects of local delivery of recombinant fusion
protein osteoprotegerin (OPG‐Fc) and bisphosphonate zoledronate on bone and …

Objective: To investigate the level of osteoprotegerin (OPG) in gingival crevicular fluid (GCF)
during tooth movement. Materials and Methods: Twelve patients (13–17 years of age) …

INTRODUCTION: In orthodontic treatment, teeth can relapse after tooth movement without
retention. The aim of this study was to evaluate the inhibition effects of local osteoprotegerin …

Relapse after orthodontic tooth movement is a significant problem in orthodontics. The
purpose of this study was to examine the efficacy of the osteoclast inhibitor osteoprotegerin …

Structured Abstract Objectives To determine minimal dose levels required for local inhibition
of orthodontic relapse by recombinant OPG protein (OPG‐Fc), while also determining effects …

Background and objectives: Anchorage is one of the most challenging sides in orthodontics.
The use of biological modulators that inhibit osteoclasts could be a solution to address these …