… regulation in sunitinib resistant metastatic clear cell renal cell carcinoma through
induction of epithelial-to-mesenchymal transition and hypoxia resistance. J Urol. 2013;189:1930–1938. …

… However, to the best of our knowledge, no literature on resistance to … sunitinib resistance.
We will discuss data from preclinical and clinical studies on mechanisms of sunitinib resistance…

… that is produced by various drug resistance mechanisms. In this … of sunitinib resistance; 2)
strategies to overcome sunitinib resistance and 3) potential predictive biomarkers of sunitinib …

… Sunitinib is one of the most widely used targeted therapeutics for renal cell carcinoma (RCC),
but acquired resistance against targeted therapies remains a major clinical challenge. To …

… cell carcinoma (RCC). The purpose of this study was to understand the mechanism of
resistance to sunitinib, … We hypothesized that sunitinib-induced upregulation of the prometastatic …

… Second, in the construction of sunitinib resistant cell lines, an increased sunitinib
concentration of roughly 1 μM higher each time may limit the tolerance of cells. Besides, the final …

… Aim: To generate sunitinib-resistant renal cell carcinoma (RCC) cell lines and identify
miRNAs contributing to sunitinib resistance. Materials and Methods: Two RCC cell lines, ACHN …

… sunitinib-resistant metastatic site. Next, we showed that sunitinib-sensitive 786-O cells acquired
resistance … overcame the sunitinib-resistance in Caki-1 cells. Histopathological analyses …

… metabolism of sunitinib-resistant cells under sunitinib were similar to those of renal cancer
cells without sunitinib. Glutamine, a non-essential amino acid, is taken up by cells via solute …

… cell renal carcinoma who initially had a response to sunitinib … Established xenografts were
treated with sunitinib. Tumor size… Plasma as well as tissue levels for sunitinib were assessed. …