… Insight into the molecular mechanisms of resistance will help … discuss molecular mechanisms
of resistance to sunitinib and … response and resistance to treatment with sunitinib, and …

… underlying these undesirable sunitinib-associated side … of sunitinib and minimize adverse
events. Here, we focus on new insights into molecular mechanisms that may mediate sunitinib-…

… Sunitinib showed clinical activity in patients with renal cell cancer and in patients with
imatinib-resistant … A better understanding of mechanisms involved in resistance to sunitinib …

… Thus, the search for genetic and molecular mechanisms of multiple drug resistance began.
From some of the earliest studies performed 40 years ago it became apparent that selection …

… that is produced by various drug resistance mechanisms. In this review, we discuss: 1)
molecular mechanisms of sunitinib resistance; 2) strategies to overcome sunitinib resistance and 3…

… sunitinib exposure would induce tumor cell resistance. We found that sunitinib resistance
of tumor … This sunitinib resistance mechanism is transient as shown by recovery after drug-free …

… of the angiogenesis pathway in RCC, the emerging molecular mechanisms of sunitinib
resistance, and the approaches to overcome resistance to sunitinib in RCC are discussed. …

… In order to address this question, we studied the molecular mechanisms of SU resistance
in vitro and in patient-derived tumors. Methods: We studied the in-vitro effects of IM or SU on …

… sunitinib; accordingly, we believe that this model may be suitable to investigate the molecular
mechanism … activity of axitinib in RCC cells acquiring a phenotype resistant to sunitinib. …

… , various mechanisms of acquired resistance that circumvent … mechanisms account for
most of the remaining resistance. … the molecular nature of resistance to imatinib and sunitinib. …