… In this review, we discuss: 1) molecular mechanisms of sunitinib resistance; 2) strategies to
overcome sunitinib resistance and 3) potential predictive biomarkers of sunitinib resistance. …

… biomarkers that predict response and resistance to treatment with … on resistance to pazopanib
has yet been published. Therefore, the focus of this review will be on sunitinib resistance. …

… resistance need to be understood in order to make accurate predictions. This article briefly
reviews candidate biomarkers of sunitinib … suitable predictive and prognostic biomarkers for …

… studies have focused on sunitinib resistance. Identification of molecular pathways, discovery
of sunitinib resistance biomarkers and construction of various prognostic models in RCC …

… We previously found that sunitinib sequestration in lysosomes of tumor … on predictive
biomarkers for VEGF-targeted therapy in patients with RCC to gain insight in clinical drug resistance …

… -associated pathways and promoted the formation of sunitinib resistance in … sunitinib
resistance in ccRCC, which we believe could bring new insights into the mechanisms of resistance …

… Moreover, SOX9 is highly expressed in RCC, which is involved in sorafenib/sunitinib
resistance through activation of RAF/MEK/ERK pathway. RCC patients with low SOX9 expression …

… sunitinib, sorafenib, axitinib and pazopanib. However, there is currently a lack of prognostic
and predictive biomarkers … The mechanisms of resistance to targeted therapy have not been …

… prognostic biomarkers … sunitinib resistance is closely related to the immune function especially
T lymphocyte founction of the body. In summary, genes that may affect sunitinib resistance …

… Our findings confirmed circulating VEGF-A as a prognostic biomarker; sVEGFR3 level was
… study to further our understanding of treatment resistance, both primary and acquired. A five-…