Platelet responses to thrombin are at least partly mediated by a G-protein-coupled receptor
whose NH 2 terminus is a substrate for thrombin. In the present studies we have examined …

Based upon its recently cloned nucleotide sequence, the human platelet thrombin receptor
is thought to be formed by a single polypeptide chain with seven transmembrane domains …

Thrombin is among the most potent of the physiological stimuli for platelets. In response to
thrombin, platelets change shape from discoid to spherical, secrete the contents of their …

How do proteases that interact with the cell surface cause intracellular signaling events?
One answer to this question was provided by the recent cloning and characterization of a …

We recently isolated a cDNA clone encoding a functional platelet thrombin receptor that
defined a unique mechanism of receptor activation. Thrombin cleaves its receptor's …

High and Moderate Affinity Pathways for α-Thrombin-Induced Platelet Activation Page 1
MINIREVIEW High and a-Throm Moderate Affinity Pathways for bin-Induced Platelet Activation …

Platelets after challenge with α-thrombin alone, collagen alone or thrombin/collagen mixture
were observed to increase the rate of activation of prothrombin by factor Xa in the presence …

In vivo, thrombo-occlusive events at sites of atherosclerotic stenosis and plaque rupture are
the principal cause of heart attacks and strokes, are dependent on the action of platelets and …

Platelet activation by thrombin is critical for hemostasis and thrombosis. Structure-function
studies with a recently cloned platelet thrombin receptor suggest that a hirudin-like domain …

Activated thrombin receptors on human umbilical vein endothelial cells rapidly undergo
homologous desensitization, leaving the cells unable to respond to thrombin. The present …