The peptide LSARLAF causes platelet secretion and aggregation by directly activating the integrin αIIbβ3
JM DERRICK, DB TAYLOR, RG LOUDON… - Biochemical …, 1997 - portlandpress.com
A novel peptide (designed to bind to αIIbβ3) caused platelet aggregation and aggregation-
independent secretion of the contents of α-granules in an αIIbβ3-dependent fashion. The …
independent secretion of the contents of α-granules in an αIIbβ3-dependent fashion. The …
Peptide LSARLAF activates αIIbβ3 on resting platelets and causes resting platelet aggregate formation without platelet shape change
JM Derrick, RG Loudon, TK Gartner - Thrombosis research, 1998 - Elsevier
Adhesion of resting platelets to fibrinogen was enhanced by a peptide which was designed
to bind near the presumptive fibrinogen γ-chain binding site of the α subunit of the integrin …
to bind near the presumptive fibrinogen γ-chain binding site of the α subunit of the integrin …
[HTML][HTML] αIIbβ3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause α-granule secretion by …
MJ Cho, J Liu, TI Pestina, SA Steward… - Journal of Thrombosis …, 2003 - Elsevier
The peptide LSARLAF (LSA) causes αIIbβ3-dependent platelet activation that results in α-
granule secretion and aggregation. LSARLAF-induced, αIIbβ3-mediated outside-in …
granule secretion and aggregation. LSARLAF-induced, αIIbβ3-mediated outside-in …
Distinct domains of αIIbβ3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an αIIbβ3 interacting peptide
JM Derrick, SJ Shattil, M Poncz… - Thrombosis and …, 2001 - thieme-connect.com
The peptide LSARLAF causes αIIbβ3-dependent platelet activation exemplified by secretion,
aggregation, spreading and adhesion on fibrinogen, and tyrosine phosphorylation. αIIbβ3 …
aggregation, spreading and adhesion on fibrinogen, and tyrosine phosphorylation. αIIbβ3 …
The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa
AC Pearce, P Wonerow, SJ Marshall… - Biochemical …, 2004 - portlandpress.com
The seven-amino-acid peptide LSARLAF has been reported to activate platelets via the
integrin GPIIb-IIIa (glycoprotein IIb-IIIa). Activation by LSARLAF is reinforced by release of …
integrin GPIIb-IIIa (glycoprotein IIb-IIIa). Activation by LSARLAF is reinforced by release of …
Interaction of β3 integrin-derived peptides 214–218 and 217–231 with αIIbβ3 complex and with fibrinogen Aα-chain
I Wierzbicka, MA Kowalska, EC Lasz, DH Farrell… - Thrombosis research, 1997 - Elsevier
β3 integrin-derived peptides 214–218 and 217–231 have been shown previously to inhibit
platelet aggregation and fibrinogen binding to platelets and to purified receptor. In this paper …
platelet aggregation and fibrinogen binding to platelets and to purified receptor. In this paper …
A novel peptide motif for platelet fibrinogen receptor recognition
J Katada, Y Hayashi, Y Sato, M Muramatsu… - Journal of Biological …, 1997 - ASBMB
To develop a specific antagonist of platelet αIIbβ3 using small linear peptides, we
synthesized a series of hexapeptides that did not have an Arg-Gly-Asp (RGD) sequence and …
synthesized a series of hexapeptides that did not have an Arg-Gly-Asp (RGD) sequence and …
Investigation of the role of adjacent amino acids to the 313–320 sequence of the αIIb subunit on platelet activation and fibrinogen binding to αIIbβ3
JV Mitsios, G Stamos, FI Rodis, LD Tsironis… - Platelets, 2006 - Taylor & Francis
The platelet integrin receptor αIIbβ3 plays a critical role in thrombosis and haemostasis by
mediating interactions between platelets and several ligands, primarily fibrinogen. We have …
mediating interactions between platelets and several ligands, primarily fibrinogen. We have …
Binding of [3H]-SK&F 107260 and [3H]-SB 214857 to purified integrin αIIbβ3: Evidence for a common binding site for cyclic arginyl-glycinyl-aspartic acid peptides and …
A Wong, SM Hwang, K Johanson, J Samanen… - … of Pharmacology and …, 1998 - ASPET
The aggregation of activated platelets is mediated by the binding of fibrinogen to its cell
surface receptor, the integrin α IIb β 3. The recognition of fibrinogen by α IIb β 3 depends, in …
surface receptor, the integrin α IIb β 3. The recognition of fibrinogen by α IIb β 3 depends, in …
Effect of synthetic peptides corresponding to residues 313–332 of the αIIb subunit on platelet activation and fibrinogen binding to αIIbβ3
JV Mitsios, AP Tambaki, M Abatzis… - European journal of …, 2004 - Wiley Online Library
The platelet integrin receptor αIIbβ3 plays a critical role in thrombosis and haemostasis by
mediating interactions between platelets and several ligands but primarily fibrinogen. It has …
mediating interactions between platelets and several ligands but primarily fibrinogen. It has …