In eukaryotic organisms a wide range of regulatory mechanisms are required to complete
the developmental program. Recently, the information contained in the histone code has …

ATP-dependent chromatin remodeling is performed by multi-subunit protein complexes.
Over the last years, the identity of these factors has been unveiled in yeast and many …

In Saccharomyces cerevisiae histone H2B is ubiquitylated at lysine 123 in a process
requiring the E2-ubiquitin conjugase, Rad6. We have analyzed gene expression in a strain …

组蛋白的甲基化修饰主要是由一类含有SET 结构域的蛋白来执行的, 组蛋白甲基化修饰参与异
染色质形成, 基因印记, X 染色体失活和转录调控等多种主要生理功能, 组蛋白的修饰作用是表观 …

In many organisms, repetitive DNA serves as a trigger for gene silencing. However, some
gene expression is observed from repetitive genomic regions such as heterochromatin …

Ubiquitin serves as a molecular zipcode to direct and sort ubiquitinylated proteins into
distinct biological pathways. Although novel modes of ubiquitin interaction have recently …

泛素在真核生物体内广泛存在, 泛素化修饰是转录后的修饰方式之一; 组蛋白是染色质的主要
成分之一, 与基因的表达有密切关系. 组蛋白的泛素化修饰与经典的蛋白质的泛素调节途径不同 …

Proper establishment, maintenance and removal of covalent post-translational modifications
on histones are essential for normal cell physiology. In this issue, Nicolas et al. describe the …

Eukaryotic DNA is packaged into chromatin, the basic unit of which is the nucleosome,
consisting of DNA wound around histone protein complexes. There are four core histones …

The developmental switch from vegetative to reproductive growth–also known as flowering–
is a critical transition in the life cycle of flowering plants. This transition is developmentally …