Covalent modifications of histones are central to the regulation of chromatin dynamics, and,
therefore, many biological processes involving chromatin, such as replication, repair …

DNA is organized into a hierarchy of structures, resulting in the level of compaction required
to pack 2m of DNA into a nucleus with a diameter of 10μm. The orderly packaging of DNA in …

Histones are subject to a complex and dynamic set of covalent modifications that are thought
to be involved in the modulation of transcription during development, in X chromosome …

Alteration of chromatin is central to genomic regulation. Chromatin is composed of
nucleosomes which are particles consisting of DNA in association with an octamer of two …

Mutations in the molecular pathways that regulate cell proliferation, differentiation, and cell
death all contribute to cancer formation. Enzymes that covalently modify histones affect …

Posttranslational modifications of histones are coupled in the regulation of the cellular
processes involving chromatin, such as transcription, replication, repair, and genome …

Ubiquitin (Ub) is a 76-amino acid protein that is ubiquitously distributed and highly
conserved throughout eukaryotic organisms. Whereas the extreme C-terminal four amino …

Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …

Histones undergo several different post-translational modifications that control a variety of
physiological processes. These covalent modifications show substantial cross-regulation …

It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …